Inhibition of Hepatic Drug Metabolism CBD can interact with a number of different other pharmaceuticals. This is because it inhibits the activity of the liver enzymes known as cytochrome P450. These enzymes metabolize pharmaceutical drugs. If you take high doses of CBD, it can temporarily neutralize the activity of P450 and alter the way that you metabolize a drug. This effect is similar to eating a portion of grapefruit. Thus, this is viewed as a minor side effect. That being said, if you plan on taking CBD, consult your doctor first.
Dry Mouth Some people report experiencing dry mouth when they take CBD. This is caused by the endocannabinoid system and how it’s involved in the secretion of saliva. Activation of submandibular glands leads to the lessened production of saliva. Dry mouth makes you thirty and uncomfortable, but it is in no way dangerous.
Increased Tremor in Parkinson’s It should be noted that the increased tremor only occurs with a high dose of CBD. When taken in large doses, it can worsen muscle movement in Parkinson’s disease sufferers. But there are other studies that have found the opposite. If you find that CBD is affecting your Parkinson’s, then be sure to lower your dose or discontinue. Always consult your doctor before you start taking CBD with Parkinson’s disease.
Low Blood Pressure When you take a higher dose of CBD oil it can drop your blood pressure. Sometimes people report feeling lightheaded when this happens. If you’re on medication for blood pressure then be sure to consult your doctor before taking CBD.
Lightheadedness Again, this is associated with the lowering of blood pressure. This side effect is temporary and is often fixed when you consume a cup of coffee or tea. These will raise your blood pressure.
Drowsiness When taken in high doses, CBD can lead to drowsiness. Don’t operate heavy machinery or drive when you take high doses of CBD. But take note: in most other cases CBD is wake-inducing. But everybody is different, so be sure to notice the symptoms. As you can see from these side effects, there’s no threat of overdosing on CBD, but when taken in large doses there is a chance for side effects. That’s why it’s important to take the right dosage and stay aware of how your body is responding. Always consult a doctor before beginning treatment with CBD.